Establishment of drug-resistant HBV small-animal models by hydrodynamic injection
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چکیده
منابع مشابه
Establishment of drug-resistant HBV small-animal models by hydrodynamic injection
In antiviral therapy of hepatitis B virus (HBV) infection, drug resistance remains a huge obstacle to the long-term effectiveness of nucleoside/tide analogs (NAs). Primary resistance mutation (rtM204V) contributes to lamivudine (LAM)-resistance, and compensatory mutations (rtL180M and rtV173L) restore viral fitness and increase replication efficiency. The evaluation of new anti-viral agents aga...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2014
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2014.06.009